C H O L I N E B I T A R T R A T E
In the 1970’s, researchers discovered the connection between the precursor choline and acetylcholine. Every cell
in the human body uses choline to build its outer membrane, which keeps it from being dissolved in the
bloodstream.
Brain Health:
 Due to its effect on the brain, choline has been shown to help with symptoms relating to Alzheimer’s,
dementia, and other age-related memory conditions. Aside from cognitive diseases and conditions,
choline is also helpful for Huntington’s, asthma, allergies, Tourette’s, and schizophrenia. However, the Bi
tartate form of Choline, although being easily absorbed, does not so easily cross the blood brain barrier
(BBB), such as the acetylcholine amino acid.
Fat loss:
 Although some choline bitatrate will convert to acetylcholine and make it to the brain, the primary use of
choline bi tartrate is fat loss by lipolysis, which is the use of fat over glucose as the body’s primary energy
source. It may also be beneficial for the prevention of future weight gain and prevention of fatty liver
disease. Many athletes also take choline to help delay fatigue. Athletes that benefit the most are weight
lifters and body builders, although endurance athletes also benefit. Choline works best pre exercise as
working out will allow this fat to burn at an even faster rate. Choline is an “old school” amino acid to take
as a “stack’ with carnitine and a small amount of caffeine.
Methylation:
 In order for choline to be used as a methyl donor, it is first oxidized to betaine, which is mediated by the
rate-limiting enzyme CHDH. Betaine then donates its labile methyl group to homocysteine for its
remethylation to methionine. After methionine is converted to the universal methyl donor Sadenosylmethionine, the choline- or betaine-derived methyl groups can be used in various methylation
reactions.
Side effects and contraindications:
 Consuming a high amount of choline may cause you to have a fishy body at approx 10 to 16 g a day can
cause this undesirable effect and also cause you to sweat and salivate profusely. These conditions are
caused by an increased amount of trimethylamine, which is a byproduct of metabolizing choline.
 Low blood pressure. Taking more than 7 to 8 g of choline can significantly decrease your blood pressure,
leading to hypotension. This can cause dizziness and fainting.
Interesting fact: Choline bitartrate provides about 7 times as much choline as the more commonly used
phosphatidylcholine supplements and up to 10 times as much choline as lecithin, although as stated, not
all crosses the BBB. Choline bitartrate will not cause stomach upset, aspirin allergies, or "tingly"
sensations, all of which are cause by the salicylate part of the product, not the choline itself
Dosage: 1gm: I – 3 x a day for weight loss pre exercise
*Note: HealthWise® L-Choline Bitartrate contains 99% pure pharmaceutical grade L-Choline.
No more than 1% silica is added as an excipient.